Research

August 19, 2021

A new understanding of the inner workings of CAR-T cell therapy

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic researchers have biomanufactured chimeric antigen receptor-T cell therapy  (CAR-T cell therapy) in a new way to track the cells’ cancer fighting journey and predict toxic side effects. This Mayo Clinic breakthrough, published in Cancer Immunology Research, also could unravel the mystery of how to unleash CAR-T cell therapy to destroy solid tumors. “This […]

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Tags: #Biomanufacturing, #CAR-T cell therapy, #Dr. Saad Kenderian, #Mayo Clinic Center for Regenerative Medicine, #regenerative iimmunotherapies


August 12, 2021

Regenerating the rotator cuff

By Susan Buckles Susan Buckles (@susanbuckles)

Preclinical studies discovered a cell-free bioactive material developed at Mayo Clinic triggered healing of one of the most common shoulder injuries. This Mayo Clinic research, published in Biomaterials, documented that purified exosome product —  also known as PEP — promoted repair of rotator cuff injuries faster and more effectively than surgery alone. The rotator cuff […]

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Tags: #Bioetherapeutics, #Dr Chunfeng Zhao, #Extracelluar vesicles, #Mayo Clinic Center for Regenerative Medicine, #Purified exosome products, #Regenerative biotherapeutics, #Rotator cuff injuries


August 5, 2021

The importance of individualized regenerative medicine

By Susan Buckles Susan Buckles (@susanbuckles)

Individualized screening, guided by artificial intelligence (AI) and biomarkers, can optimize the transformative potential of regenerative medicine, according to a Mayo Clinic study. The paper, published in Biomarkers in Medicine, maintains that using new scientific tools to match the right biotherapeutics to the right patient ushers in the era of achieving tailored regenerative care. Conversely, […]

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Tags: #artificial intelliegence, #Cardiac regeneration, #cardiopoietic cells, #Dr. Andre Terzic, #Dr. Satsuki Yamada, #genetic testing, #Mayo Clinic Center for Regenerative Medicine


June 24, 2021

Demystifying healing potential of stem cells

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic research has discovered proteins secreted by human stem cells that act as a “magic potion” to drive healing after a heart attack. The research uncovered that these cell-released regenerative particles harbor a pattern of functions mirrored in repair of the diseased heart, linking stem cell-transmitted information to the beneficial response of the recipient […]

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Tags: #Cardiac regeneration, #cardiopoietic cells, #Dr. Andre Terzic, #Dr. Kent Arrell, #Heart attack, #myocardial infarction


June 17, 2021

Could regenerative medicine relieve neck, back pain?

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic is looking to regenerative medicine as a potential long-term solution for degenerative disk disease that has for years eluded medical science. Millions of people in the U.S. are afflicted with chronic neck and back pain that often comes after years of wear and tear on the spine. Current treatments provide only temporary relief […]

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Tags: #back and neck pain, #bone marrow aspirate concentrate, #Center for Regenerative Medicine, #degenerative disk disease, #Dr. Wenchun Qu, #platelet rich plasma


June 11, 2021

Regenerative pipeline for spinal cord repair

By centerforregmedmc centerforregmedmc (@centerforregmedmc)

Article by Sara Tiner Mayo Clinic research is learning how stem cell therapy can treat neurodegenerative diseases. Mayo is among the first to study whether stem cell therapy might trigger healing for spinal cord injury. Research is ongoing in preclinical models, but it also has advanced from discovery science to early clinical trials. It’s a […]

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Tags: #Center for Regenerative Medicine, #Dr. Anthony Windebank, #Dr. Mohamad Bydon, #mesenchymal stem cells, #Spinal cord injury research, #Spinal cord regeneration


May 20, 2021

Inspired to deliver new regenerative healing solutions

By Susan Buckles Susan Buckles (@susanbuckles)

Growing up the son of a neurologist in China, Ao “Kevin” Shi, often would read his mother’s medical journals that featured Mayo Clinic research. Inspired, he pursued a career as a physician-scientist. Shi is now writing his own scholarly papers at Mayo Clinic that could transform care for people with peripheral vascular disease. Shi is […]

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Tags: #Ao Shi, #Dr. Atta Behfar, #extra cellular vesicles, #Ischemic healing, #Ischemic wounds, #Mayo Clinic Center for Regenerative Medicine, #Regenerative Sciences Training Program, #Wound healing


May 13, 2021

From the researcher: Dr. Scarisbrick explains cholesterol, research and regeneration

By centerforregmedmc centerforregmedmc (@centerforregmedmc)

Article by Sara Tiner Isobel Scarisbrick, Ph.D., directs the Neural Repair Laboratory within Mayo Clinic’s Department of Physical Medicine and Rehabilitation. Her lab examines central nervous system repair after injury, such as traumatic spinal cord injury or a disease like multiple sclerosis (MS). A major area of innovation for the lab is improving nerve regeneration […]

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Tags: #cholesterol, #Dr. Isobel Scarisbrick, #Mayo Clinic Center for Regenerative Medicine, #Mayo Clinic Neural Repair Lab, #Spinal cord injury research


May 7, 2021

How regenerative medicine is advancing ALS research

By Susan Buckles Susan Buckles (@susanbuckles)

May is ALS Awareness Month, a time to reflect on the role of regenerative medicine research in advancing understanding and treatment of  amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease. This neurodegenerative disorder causes nerve cells in the brain and spinal cord to die, blocking signals to the muscles. That results in paralysis that robs […]

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Tags: #amyotrophic lateral sclerosis, #Dr. Anthony Windebank, #Dr. Nathan Staff, #Lou Gehrig's disease, #Mayo Clinic Center for Regenerative Medicine, #medical research


April 28, 2021

Mayo Clinic preclinical study triggers wound healing, skin regeneration

By Susan Buckles Susan Buckles (@susanbuckles)

ROCHESTER, Minn. — Difficult-to-treat, chronic wounds in preclinical models healed with normal scar-free skin after treatment with an acellular product discovered at Mayo Clinic. Derived from platelets, the purified exosome product, known as PEP, was used to deliver healing messages into cells of preclinical animal models of ischemic wounds. The Mayo Clinic research team documented […]

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Tags: #Dr. Ao Shi, #Dr. Atta Behfar, #Dr. Steven Moran, #Mayo Clinic Center for Regenerative Medicine, #Purified exosomal product, #Wound healing


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