Research

June 27, 2022

Biomanufacturing 101: Understanding a new era of therapeutics

By Susan Buckles Susan Buckles (@susanbuckles)

Advancing cellular discoveries from clinical trials to commercial therapy is a cornerstone of Mayo Clinic’s strategic emphasis on biomanufacturing. The long-term vision is to provide new cures for patients with unmet needs. “Biomanufacturing is a type of manufacturing that utilizes sources from the human body — cells, blood, enzymes, tissues, genes or genetically engineered cells […]

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Tags: #biologics, #biotherapeutics, #Dr. Julie Allickson, #Mayo Clinic Center for Regenerative Medicine, #stem cell research


June 20, 2022

Addressing diversity barriers to regenerative medicine

By Susan Buckles Susan Buckles (@susanbuckles)

With the promise of regenerative medicine comes the risk of widening health care disparities. Sometimes the newest discoveries, such as regenerative interventions, are out of reach for people in diverse ethnic or socioeconomic groups — or they may not understand or trust new options for healing. Mayo Clinic is trying to overcome those barriers by […]

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Tags: #diversity, #Dr. Zubin Master, #Dr.Jorge Mallea, #equity and inclusion, #Mayo Clinic Center for Regenerative Medicine, #regeneration for all


May 26, 2022

Molecular mapping of the heart to predict disease susceptibility

By Susan Buckles Susan Buckles (@susanbuckles)

Vulnerability to heart disease can be projected before symptoms occur, Mayo Clinic discovered in preclinical research. This proof-of-concept study revealed that heart muscle changes indicate who is vulnerable to disease later in life. These changes can be detected from blood samples through comprehensive protein and metabolite profiling. This exploratory mapping, conducted in the Marriott Family […]

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Tags: #Dr. Andre Terzic, #Dr. Satsuki Yamada, #Heart disease, #Mayo Clinic Center for Regenerative Medicine, Dr. Kent Arrell


May 18, 2022

Training the next generation in regenerative medicine

By Susan Buckles Susan Buckles (@susanbuckles)

Mayo Clinic is welcoming a new class of five students into the Regenerative Sciences track within the doctoral program in Mayo Clinic’s Graduate School of Biomedical Sciences, one of the first programs of its kind. Training the next generation of physicians and scientists to research, develop and deliver new biotherapies is critical to advancing the […]

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Tags: #Aubrey Berger, #Dr. Isobel Scarisbrick, #Jimmy Cai, #Kyle Knofdzvnski, #Mayo Clinic Center for Regenerative Medicine, #Rafaela Simones Torigo, #Regenerative Sciences Training Program, #regenerative; medicine education, #Tiana Salomon


May 5, 2022

What’s behind patient requests for stem cells?

By Susan Buckles Susan Buckles (@susanbuckles)

In one of the first studies of its kind, Mayo Clinic analyzed a large group of patients to understand their motivations for seeking stem cell therapies and whether expectations are grounded in science. The findings could help health care professionals cut through misleading claims and better counsel patients. This research by Jennifer Arthurs; Zubin Master, […]

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Tags: #biomedical ethics, #Dr. Shane Shapiro, #Dr. Zubin Master, #Jennifer Arthurs, #Mayo Clinic Center for Regenerative Medicine, #Orthobiologics, #Regenerative Medicine Therapeutic Suites, #Stem cell therapy, #stem cells


April 7, 2022

Saranya Wyles: Regenerating damaged skin

By Susan Buckles Susan Buckles (@susanbuckles)

When she was just 8 years old, Saranya Wyles, M.D., Ph.D., would recite the stages of wound healing in Latin terms — rubor, tumor, calor, dolor and functio laesa— to her father at the dinner table. Decades later, that ingrained knowledge would be a cornerstone of her regenerative medicine research, education and practice at Mayo […]

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Tags: #alopecia, #cellular senescence, #dermatology, #Regenerative medicine education, #Saranya Wyles, #scarring, #skin aging, #Wound healing


March 24, 2022

Regenerating damaged vocal cords

By Susan Buckles Susan Buckles (@susanbuckles)

Cells from amniotic membrane show potential of repairing vocal cord injuries that don’t respond to standard care, Mayo Clinic discovered in preclinical research. The placental membrane provides a rich source of epithelial cells that could regenerate damaged tissue. Research by David Lott, M.D., a laryngeal surgeon in Arizona, found epithelial cells extracted after childbirth triggered […]

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Tags: #Dr. David Lott, #epithelial cells, #Mayo Clinic Center for Regenerative Medicine, #Vocal cord injury, #Vocal cord regeneration


March 3, 2022

The immune system and bone regeneration

By Susan Buckles Susan Buckles (@susanbuckles)

Growing up as a student athlete in Cincinnati, Joe Panos had more than his fair share of visits to the orthopedist for sports injuries. The care he received for conditions ranging from pitcher’s elbow to soccer sprains so impressed him that he vowed one day to be the physician instead of the patient. Now Panos, […]

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Tags: #BMP-2 growth factor, #bone regeneration, #Dr. Christopher Evans, #Mayo Clinic Alix School of Medicine, #Mayo Clinic Center for Regenerative Medicine, #ON Foundation, #Orthoregeneration Award


February 25, 2022

Unleashing the body’s ability to heal

By Susan Buckles Susan Buckles (@susanbuckles)

“We are the patient’s last, best hope,” has been the motto of the Immune, Progenitor and Cell Therapeutics lab, also known as the IMPACT lab, at Mayo Clinic. This lab specializes in clinical and investigative use of cells as living drugs within the body to fight disease and initiate healing when standard therapies don’t work. […]

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Tags: #cell therapies, #Department of Laboratory Medicine and Pathology, #Dr. Allan Dietz, #Immune Progenitor and Cell Therapy Lab, #Mayo Clinic Center for Regenerative Medicine


February 15, 2022

Regenerative Medicine Minnesota awards 5 research grants to Mayo Clinic

By Susan Buckles Susan Buckles (@susanbuckles)

Regenerative Medicine Minnesota, a statewide bipartisan initiative, has awarded five grants to Mayo Clinic investigators to advance new therapeutic options for osteoarthritis, liver disease, rotator cuff injuries and neurological birth defects. People in Minnesota and beyond struggle with chronic diseases such as heart disease, arthritis and diabetes, and standard care doesn’t always ease the symptoms. […]

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Tags: #Dr. Aaron Krych, #Dr. Chunfeng Zhao, #Dr. Jennifer Westendorf, #Dr. Qiuying Liu, #Dr. Rory Smoot, #hip cartilage injury, #osteoarthritis, #rotator cuff injury


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