Research
November 30, 2023
Rebuilding bigger, stronger hearts
Reprint from Mayo Clinic Alumni magazine, 2023, issue 3 Timothy Nelson, M.D., Ph.D., intended to be a cardiothoracic surgeon. “As a student in the Medical Scientist Training Program at the Medical College of Wisconsin, I observed a lot of cases and remember the joys of giving families hope that we could repair defects,” he says. “I […]
Tags: #cardiomyocytes, #Dr. Timothy Nelson, #Hypoplastic Left Heart Syndrome, #Mayo Clinic Center for Regenerative Biotherapeutics
August 18, 2023
Advancing understanding of CAR-T cell therapy for cancer
By MayoRegMed 
By Kate Ledger This article on a Mayo Clinic Regenerative Sciences Training Program student is taken from a series of articles that feature the work of graduate students as they near the end of their Ph.D. training at Mayo Clinic Graduate School of Biomedical Sciences. Students talk about their research journeys, lessons they learned along the […]
Tags: #biomedical research, #CAR T-cell therapy, #Claudia Manriquez Roman, #Mayo Clinic Center for Regenerative Biotherapeutics, #Regenerative Sciences Training Program
August 10, 2023
Regenerative Medicine Minnesota awards 3 grants to Mayo Clinic researchers
Regenerative Medicine Minnesota, a statewide bipartisan initiative, has awarded three grants to Mayo Clinic for research to improve cancer treatment and nerve regeneration. Recognizing the need for a new approach to healthcare, Minnesota lawmakers established Regenerative Medicine Minnesota a decade ago. This state funded initiative is focused on advancing regenerative medicine in research, technology, education […]
Tags: #CAR-T cell therapy, #Dr. Alexander Shin, #Dr. Ismail Can, #Dr. Kevin Loutherback, #Mayo Clinic Center for Regenerative Biotherapeutics, #nerve regeneration
July 20, 2023
Could bioprinted skin uncover a new treatment for eczema?
Mayo Clinic has developed its first 3D prototype of human skin bioprinted to model inflammatory skin disease. 3D bioprinting is a technology that mixes bioinks with living cells to print natural tissue-like structures in three dimensions. This new technology provides the most human-like skin model for studying inflammatory conditions such as atopic dermatitis — more […]
Tags: #3D bioprinting, #Atopic dermatitis, #biomedical research, #cell therapy, #Center for Regenerative Biotherapeutics, #Dr. Saranya Wyles, #eczema, #medical research, #Skin 3D bioprinting
August 15, 2022
Mayo Clinic announces a strategic collaboration for a new era of biomanufacturing
Mayo Clinic today announced a strategic collaboration in biomanufacturing to deliver novel biotherapeutics for rare and complex conditions. The collaboration brings together science, engineering and manufacturing to advance Mayo Clinic’s vision of bringing new cures to clinical care. The focus will be on therapies derived from human sources known as biologics — cells, blood, enzymes, […]
Tags: #biologics, #cell therapy, #Dr. Julie Allickson, #gene therapy, #Mayo Clinic Center for Regenerative Medicine, #National Resilience Inc.
August 2, 2022
Options for laryngeal regeneration
Mayo Clinic is using 3D printing as a new option to heal the larynx after cancer or traumatic injury. David Lott, M.D., a Mayo Clinic otolaryngologist and head and neck surgeon, is an expert who can speak about a pioneering procedure using 3D bioimplants and tissue engineering to regenerate the larynx, more commonly known as […]
Tags: #Dr. David Lott, #laryngeal cancer, #laryngectomy, #larynx transplant, #Mayo Clinic Center for Regenerative Medicine, #Tissue engineering
July 18, 2022
A preclinical step toward treating chronic dry mouth
Mayo Clinic researchers replicated chronic dry mouth from radiation damage in preclinical models, laying the foundation for stem cell research to regenerate salivary tissue after cancer. This discovery uses targeted X-radiation to mimic human injury and establish a lab model for testing cellular therapies for dry mouth. The study is published in Radiation Research. “The […]
Tags: #Dr. Jeffrey Janus, #Dr. Nagarajan Kannan, #Dry mouth, #head and neck cancer, #Mayo Clinic Center for Regenerative Medicine, #xerostomia
June 27, 2022
Biomanufacturing 101: Understanding a new era of therapeutics
Advancing cellular discoveries from clinical trials to commercial therapy is a cornerstone of Mayo Clinic’s strategic emphasis on biomanufacturing. The long-term vision is to provide new cures for patients with unmet needs. “Biomanufacturing is a type of manufacturing that utilizes sources from the human body — cells, blood, enzymes, tissues, genes or genetically engineered cells […]
Tags: #biologics, #biotherapeutics, #Dr. Julie Allickson, #Mayo Clinic Center for Regenerative Medicine, #stem cell research
June 20, 2022
Addressing diversity barriers to regenerative medicine
With the promise of regenerative medicine comes the risk of widening health care disparities. Sometimes the newest discoveries, such as regenerative interventions, are out of reach for people in diverse ethnic or socioeconomic groups — or they may not understand or trust new options for healing. Mayo Clinic is trying to overcome those barriers by […]
Tags: #diversity, #Dr. Zubin Master, #Dr.Jorge Mallea, #equity and inclusion, #Mayo Clinic Center for Regenerative Medicine, #regeneration for all
May 26, 2022
Molecular mapping of the heart to predict disease susceptibility
Vulnerability to heart disease can be projected before symptoms occur, Mayo Clinic discovered in preclinical research. This proof-of-concept study revealed that heart muscle changes indicate who is vulnerable to disease later in life. These changes can be detected from blood samples through comprehensive protein and metabolite profiling. This exploratory mapping, conducted in the Marriott Family […]
Tags: #Dr. Andre Terzic, #Dr. Satsuki Yamada, #Heart disease, #Mayo Clinic Center for Regenerative Medicine, Dr. Kent Arrell