Latest News and Highlights from Mayo Clinic's Center for Regenerative Medicine

Tue, Dec 6

Mayo Clinic researchers test stem cell therapy to treat arthritis

By Center for Regenerative Medicine centerforregmedmc

Researchers at Mayo Clinic’s campus in Florida have conducted the world’s first prospective, blinded and placebo-controlled clinical study to test the benefit of using bone marrow stem cells, a regenerative medicine therapy, to reduce arthritic pain and disability in knees.

The researchers say such testing is needed because there are at least 600 stem cell clinics in the U.S. offering one form of stem cell therapy or another to an estimated 100,000-plus patients, who pay thousands of dollars, out of pocket, for the treatment, which has not undergone demanding clinical study.

The findings in The American Journal of Sports Medicine include an anomalous finding —patients not only had a dramatic improvement in the knee that received stem cells, but also in their other knee, which also had painful arthritis but received only a saline control injection. Each of the 25 patients enrolled in the study had two bad knees, but did not know which knee received the stem cells. Read the rest of this entry »

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Tags: arthritis, Dr Shapiro, mayo clinic, Mayo Clinic in Florida, medical research, regenerative medicine, research, stem cells

Fri, Dec 2

Center for Regenerative Medicine to co-host World Stem Cell Summit Dec. 6-9

By Center for Regenerative Medicine centerforregmedmc

scientist-in-labThe Mayo Clinic Center for Regenerative Medicine is a co-sponsor of the 2016 World Stem Cell Summit. More than 1,200 attendees are expected at the 12th annual event in West Palm Beach, Florida. A delegation of administrators, researchers and clinical experts from Mayo Clinic will participate in featured presentations and panel discussions highlighting advances in discovery science, promising clinical trials and available therapies. Diverse topics to be covered include cardiovascular regeneration, restoring eyesight, and growing stem cells in a microgravity environment in space. Mayo Clinic experts also will be involved in panel discussions regarding education, consumer information and stem cell clinics.

Tuesday is Public Day, where panel discussions and presentations address current topics from a consumer perspective. Shane Shapiro, M.D., orthopedic surgeon, will discuss the different sources and types of stem cells, such as those from bone marrow and fat. Dr. Shapiro’s presentation will include guidance on how consumers should proceed with available regenerative medicine treatments and the differences between same-day widely available clinics and less available lab-based treatments.

Also on Public Day, Karen Krucker, stem cell therapy program manager at Mayo Clinic, will give a talk about what patients and their families need to know before getting stem cell or regenerative medicine treatment. Krucker has worked at the Regenerative Medicine Consult Service at Mayo Clinic, the first consult service established in the U.S. to provide guidance for patients and families regarding stem cell-based protocols.

Thomas Gonwa, M.D. is leading the Mayo delegation and will provide comments during the opening plenary session on Tuesday, Dec. 6. Dr. Gonwa is deputy director, Translation, in the Mayo Clinic Center for Regenerative Medicine. He oversees translational regenerative medicine infrastructure across Mayo Clinic, ensuring technological and translational readiness necessary to sustain scientific excellence, practice advancement and fulfillment of institutional and site-specific goals. Dr. Gonwa also will participate in a panel discussion on “Best Practices for Effective Collaboration.” Read the rest of this entry »

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Tags: Andre Terzic, mayo clinic, medical research, regenerative medicine, research, Shane Shapiro, stem cells, Thomas Gonwa, Timothy Nelson, World Stem Cell Summit

Tue, Nov 29

Tissue Engineering and Regenerative Medicine Lecture

By Center for Regenerative Medicine centerforregmedmc

Dr. Vacanti, right, with Andre Terzic, M.D., Ph.D., Director of the Mayo Clinic Center for Regenerative Medicine.

Dr. Vacanti, right, with Andre Terzic, M.D., Ph.D., Director of the Mayo Clinic Center for Regenerative Medicine.

Early in his career as a pediatric and transplant surgeon-scientist, Joseph P. Vacanti, M.D., was motivated by the problem of organ shortage for his tiny patients. It has led to a career long pursuit in solving the problem of organ availability for babies and young children.

In an early case, finding a liver the right size for an infant was a daunting task. The use of a reduced-size graft in a pediatric recipient had its own risks. When determined parents asked about the statistical risks to “do all that could be done,” Dr. Vacanti had to reply that there were no statistics. The procedure had never been done.

Dr. Vacanti began the nation's first liver transplantation program specifically for the pediatric population in the early 1980s at Children’s Hospital Boston. As it became apparent that donor organs would continue to be in short supply, he embarked on the field of tissue engineering.

Dr. Vacanti talked about the continuing challenge of insufficient tissue availability in his presentation, “The Clinician-Scientist and Regenerative Medicine/Tissue Engineering” at the George M. Eisenberg Foundation Lecture on Regenerative Medicine at Mayo Clinic recently. Dr. Vacanti is the co-director for the Center for Regenerative Medicine and the director for the Laboratory for Tissue Engineering and Organ Fabrication at the Massachusetts General Hospital. He serves as the Chief, Department of Pediatric Surgery, and is the John Homans Professor of Surgery at Harvard Medical School.

A pioneer of tissue engineering, Dr. Vacanti emphasized the need to create living replacement structures and to build new organs to replace tissue destroyed by disease or congenital conditions. Dr. Vacanti said the most efficient road to human therapy in regenerative medicine and tissue engineering is combining biology with technology. Incorporating manufacturing practices and quality controls in tissue engineering will drive costs down.

At Mayo Clinic, the Center for Regenerative Medicine Biotrust, the Human Cell Therapy Laboratory, the Biomaterials and Biomolecules Facility, and the Advanced Product Incubator are the four clinical facilities that comprise the Regenerative Medicine Platforms. Mayo Clinic is actively engaged in numerous clinical trials in regenerative and restorative therapies. Clinical trials are ongoing in several areas of care including neuroscience, cancer care, cardiovascular, face and hand transplant, and musculoskeletal. Mayo Clinic teams are advancing regenerative medicine techniques that repair damaged tissue and restore health by harnessing the body’s ability to heal itself.




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Tags: Andre Terzic, harvard medical school, joseph vacanti, mayo clinic, mayo clinic medical research, regenerative medicine, stem cells

Wed, Nov 23

Healing from Within: The Promise of Regenerative Medicine

By Center for Regenerative Medicine centerforregmedmc

The Mayo Clinic Center for Regenerative Medicine, in partnership with Regenerative Medicine Minnesota, recently produced a patient-focused video called, “Healing from Within: The Promise of Regenerative Medicine.” The eight-minute educational video is funded by a patient care grant from Regenerative Medicine Minnesota.

The video features  interviews with Mayo Clinic physicians and researchers, explores regenerative medicine advances and current applications, and includes information on regenerative medicine clinical trials.

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Tags: mayo clinic, regenerative medicine, Regenerative Medicine Minnesota, research, stem cells

Fri, Oct 21

National Academy of Medicine elects Mayo Clinic’s Michael Yaszemski, M.D., Ph.D.

By Center for Regenerative Medicine centerforregmedmc

Michael J. Yaszemski, M.D., Ph.D., Mayo Clinic orthopedic surgeon and researcher, has been elected to the National Academy of Medicine. Selection is one of the highest honors in medicine and recognizes individuals who have demonstrated outstanding professional achievement and commitment to service.

Dr. Yaszemski is one of two Mayo Clinic physicians to be elected this year. Andrea Cheville, M.D., physical medicine and rehabilitation researcher and director of the Cancer Rehabilitation Program at Mayo Clinic also was selected.

yaszemski-photo original“To have colleagues from distinct practice areas recognized in the same year is an incredible honor for them individually and for Mayo Clinic as a whole,” says John Noseworthy, M.D., president and CEO, Mayo Clinic. “Such recognition underscores the commitment of our physician-scientists in advancing research to address unmet patient needs, educating the next generation of physicians and scientists, and providing unparalleled care for patients and their families.”

Dr. Yaszemski has a spine surgery practice at Mayo Clinic and routinely cares for patients who have skeletal defects that require reconstruction. His clinical practice includes spinal surgery and oncologic surgery of the spine, sacrum and pelvis.

“Dr. Yaszemski is known as a strong clinical collaborator and he has built a differentiated surgical practice at Mayo Clinic. His team approach to complex spine surgery often includes colleagues in neurosurgery and is exemplary in the singular focus on the needs of the patient,” says Mark W. Pagnano, M.D., chair, Department of Orthopedic Surgery at Mayo Clinic. “Dr. Yaszemski’s surgical contributions and research advances continue to make a difference, not just for patients at Mayo Clinic but for patients nationwide and patients worldwide. His surgical skills are well-recognized amongst the nation’s spine surgeons.”

Dr. Yaszemski is the director of the Tissue Engineering and Biomaterials Laboratory. His research is in the development of biodegradable scaffold polymers to support bone regeneration and spinal cord regeneration using tissue engineering strategies. He is a deputy director within Mayo Clinic’s Center for Regenerative Medicine. His research focus areas include:

  • Biodegradable polymers
  • Bone tissue engineering
  • Spinal cord regeneration
  • Nerve tissue engineering
  • Sarcoma cell and molecular biology

Dr. Yaszemski's long-term research goal is to change the way that many common debilitating, life-threatening musculoskeletal conditions are treated. The use of biodegradable polymers in bone tissue engineering will be significant to patients with spine instability or spinal cord injuries. Read the rest of this entry »

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Tags: mayo clinic, National Academy of Medicine, Orthopedic Surgery, Regenerative Medicine Michael Yaszemski, research, stem cells

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