May 18, 2023
Like filling a pothole: Cell therapy for cartilage repair
Growing up in the Netherlands, Daniel Saris, M.D., Ph.D., was exposed to the wonders of science at a young age. He listened to his father, a physicist, when he spoke at scientific conferences. His mother, an English teacher, encouraged learning about diverse societies. These experiences would grow into Dr. Saris’ career as an orthopedic surgeon […]
Tags: #cartilage injury, #cartilage repair, #Dr. Daniel Saris, #joint replacement, #knee injury, #Mayo Clinic Center for Regenerative Biotherapeutics, #orthopedics
April 25, 2023
Orthobiologics can be nature’s healing agents
Mayo Clinic physician-scientists are working on regenerative biotherapeutics such as orthobiologics and other regenerative bioinjectables to bring advanced procedures to more patients. Orthobiologics are biological agents that stimulate healing when standard therapies don’t work. Examples are platelet-rich plasma — platelets spun from a patient’s blood that promote cell repair— and bone marrow aspirate concentrate that […]
Tags: #bone marrow aspirate concentrate, #Dr. Cody Wyles, #Dr. David Lott, #Dr. Saranya Wyles, #Dr. Shane Shapiro, #Mayo Clinic Center for Regenerative Biotherapeutics, #Orthobiologics, #Platelet-rich plasma
April 3, 2023
Pivoting toward a new strategy for fighting disease
The Mayo Clinic Symposium on Regenerative Medicine & Surgery 2023 opened today with a look at how biotherapeutics is shaping the future of medicine. “Our commitment to delivering new cures for unmet conditions is behind Mayo’s pivot to biomanufacturing,” says Julie Allickson, Ph.D., the Michael S. and Mary Sue Shannon Family Director of Mayo Clinic’s […]
Tags: #Biomanufacturing, #biotherapeutics, #cell therapies, #Dr. Julie Allickson, #gene therapies, #Mayo Clinic Center for Regenerative Biotherapeutics, #Mayo Clinic Symposium on Regenerative Medicine and Surgery
March 21, 2023
Advancing promising therapies through regulatory programs
Learn about the latest regulatory programs designed to accelerate promising new therapies toward clinical care at the Mayo Clinic Symposium on Regenerative Medicine & Surgery 2023. The event featuring nationally and internationally known speakers will be held April 3–5 at the Westin Kierland Resort and Spa in Scottsdale, Arizona. Peter Marks, M.D., Ph.D., director of […]
Tags: #cell therapies, #Dr. Peter Marks, #Dr. Richard Hayden, #Food and Drug Administration, #Mayo Clinic Center for Regenerative Biotherapeutics, #Mayo Clinic Symposium on Regenerative Medicine & Surgery, #Regenerative Medicine Advance Therapy
March 14, 2023
A twist of fate led to regenerative medicine
A chance meeting on a student shuttle bus put Wenchun Qu, M.D., Ph.D., on a new direction that years later would culminate in becoming the Jorge and Leslie Bacardi Associate Director of the Mayo Clinic Center for Regenerative Biotherapeutics in Florida. During a ride to the University of Southern California (USC) where Dr. Qu was […]
Tags: #cell therapy, #Dr. Wenchun Qu, #gene therapy, #Mayo Clinic Center for Regenerative Biotherapeutics, #physical medicine & rehabilitation, #stem cell research
February 21, 2023
Research prepares for Mayo’s first larynx transplant
Mayo Clinic has refined a preclinical model that lays the foundation for its first-ever larynx transplant. The model assesses the unique immunosuppressive needs of vascular composite allograft (VCA) transplantation, a type of transplant that requires transferring many different types of tissues, such as muscle, blood vessels and nerves, along with the organ. A larynx transplant […]
Tags: #Dr. David Lott, #laryngeal cancer, #laryngeal injury, #larynx transplant, #Mayo Clinic Center for Regenerative Biotherapeutics
February 16, 2023
Recognizing the potential of gene-modified T cells to transform medicine, researchers at the University of Pennsylvania have continued to innovate with clinical trials over the past two decades. In a convergence of science, medicine and entrepreneurship, an industry collaborator brought the first breakthrough gene therapy for cancer to market in the U.S. in 2017 — […]
Tags: #biologics, #CAR T-cell therapy, #Dr. Bruce Levine, #Dr. Richard Hayden, #Mayo Clinic Center for Regenerative Biotherapeutics, #Mayo Clinic Symposium on Regenerative Medicine and Surgery
February 2, 2023
“Rock star” baby is now a “rock star” preschooler
A child’s first steps are always exciting for parents, but for Hetty and Tyler Mollert, it was a miracle. Their daughter, Madelyn, has spina bifida, a congenital defect in which the spinal cord doesn’t develop properly. People affected by this condition sometimes have long-term disabilities, such as weakness or paralysis, that limits the ability to […]
Tags: #Fetal surgery, #Hetty Mollert, #Madelyn Mollert, #Mayo Clinic Center for Regenerative Biotherapeutics, #Myelomeningocele, #Spina Bifida
January 19, 2023
Tissue engineering techniques discovered at Mayo Clinic and Arizona State University created a humanlike vocal cord (fold) structure with the potential to produce a natural-sounding voice. The bioengineered scaffold mimics human vocal folds, with ability to vibrate and make sound. The study team reported the tissue-engineered vocal fold structure suggests potential for growing cells capable […]
Tags: #Bioengineering, #Dr. David Lott, #Mayo Clinic Center for Regenerative Biotherapeutics, #Tissue engineering, #Vocal cord damage, #Vocal fold scarring
January 12, 2023
Reprogramming stem cells to heal disease
At one point, Shinya Yamanaka, M.D., Ph.D., was so down and discouraged that he almost gave up his research into embryonic cells and their powerful potential to replace diseased cells. He was finding little interest among colleagues; funding was hard to come by; and research journals rejected his studies. Then, discovery of human embryonic cell […]
Tags: #biologics, #Dr. Shinya Yamanaka, #induced pluripotent stem cells, #Mayo Clinic Center for Regenerative Biotherapeutics, #Mayo Clinic Symposium on Regenerative Medicine and Surgery