Posts (5)

Tue, Oct 1 9:00am · Zane's story: Fetal surgery to expand lungs

Zane Fouts with parents Trevor Fouts,
Alyse Ahern-Mittelsted

Baby Zane Fouts’ boundless curiosity starts at his feet, which
he grabs and plays with happily. The energetic boy who’s full of smiles is a
trailblazer for regenerative surgery performed in a clinical trial at Mayo Clinic even before birth.

“He’s our miracle baby,” says his mother, Alyse Ahern-Mittelsted.  “He’s a rock star.”

Ahern-Mittelsted was 20 weeks pregnant when an ultrasound
showed Zane had severe congenital diaphragmatic hernia (CDH). This life-threatening
condition blocks lungs from growing enough for babies to breath on their own. Without
intervention, 70% of infants born with severe CDH die. The bombshell news came
less than a year after Ahern-Mittelsted unexpectedly lost a daughter at 31
weeks of gestation to a different condition — a failed placenta.

“We thought we were going to lose another baby. We were
really scared.”

CDH is a hole in the muscle separating the chest and abdomen.
That causes the spleen, stomach and bowels to push up into the chest cavity and
stunt lung growth. The result is small, underdeveloped lungs, known as pulmonary
hypoplasia
.  It’s a rare condition that
affects 1 in 10,000 babies.

To try to save Zane’s life, Rodrigo Ruano, M.D., Ph.D., head of Maternal Fetal Medicine at Mayo Clinic, recommended fetal endoscopic trachea occlusion surgery while Zane was still in the womb.

Rodrigo Ruano, M.D., Ph.D.

“It’s a delicate procedure. We insert a 3-to-4 millimeter
telescope through the mother and into the fetus. We advance a balloon into the
baby’s mouth and detach it from a catheter placed insidethe trachea, which is the airway of the fetus. The goal of this
surgery is to regenerate and expand the lungs,” says Dr. Ruano.  “I feel so passionately about this surgery that
I have dedicated my life to moving it toward standard of care treatment.”

When the balloon inside the fetus’ trachea inflates, it
fills the lungs with fluid, potentially causing the lungs to expand and grow. Because
a fetus breathes through the placenta, the balloon does not choke the baby.

Dr. Ruano is pioneering this procedure at Mayo Clinic
through U.S. Food and Drug Administration (FDA) -approved clinical trials with
support from the Mayo
Clinic Center for Regenerative Medicine
and a grant from Regenerative Medicine Minnesota.

While the surgery shows promise, it also comes with risk of preterm
labor and delivery. That meant the young couple from Cresco, Iowa, had a
decision to make about the health of their unborn child.

“We were told that without the surgery, our baby would only
have a 25% chance of ever coming home. With the surgery, the chances jumped to
75%,” says Ahern-Mittelsted. “We knew there was a chance this surgery might not
work. But, if this was going to give our son the best chance of survival, I
wasn’t going to second guess it.”

“After the doctor told us our options, I was looking for
more information (to help make a decision.) I looked online, but this procedure
is so new, there wasn’t a lot about it. I had to put my faith and trust in our
surgeon,” says Trevor Fouts, Zane’s father.

Surgery to place the balloon inside Baby Zane’s trachea was
performed at 27 weeks under local anesthesia and took only about 15 minutes.  

“When they were going to place the balloon, they had to move
the baby and place him in the right position. That was painful for me, but it
went fast,” she adds.

The balloon was removed at 34 weeks of pregnancy, and Zane
was born full-term at 39 weeks. How well a baby with Zane’s condition does at
birth depends on development of the lungs. Some babies whose lungs successfully
grow and develop may recover with few lingering medical issues. Others whose
lungs do not respond as well may have mild to long-term handicaps.

Immediately after birth, a breathing tube was placed in
Zane’s airway and he was connected to a ventilator. But, he was only on
machine-assisted breathing for a couple of weeks.

The balloon surgery expanded his lung capacity by about 60%.
After 52 days in the Neonatal Intensive Care Unit, he had improved enough to go
home.

Zane Fouts

“Without this procedure he likely would not have been as
healthy as he is now.  He still has a
raspy voice and has a tough time with coughs. Eventually, we expect him to live
a normal life with normal activities.  We
think he’ll be able to participate in sports, although he may need an inhaler,”
says Ahern-Mittelsted.  “I believe this
surgery pretty much saved his life.”

Dr. Ruano has performed a total of five fetal endoscopic
trachea occlusion surgeries so far at Mayo Clinic. His research team is
compiling the data to establish whether this surgery improves chances for survival
and reduces recovery time. The long-term goal is to secure FDA approval of the
balloon used in the procedure so this surgery can be offered in daily clinical
care.

Read about Dr. Ruano’s research
on fetal endoscopic trachea occlusion surgery
.

### 

Watch a video about fetal surgery.

Thu, Sep 5 8:30am · Meet researcher Saad Kenderian: Using regenerative cell therapy to recognize and attack cancer

For as long as he can remember, Saad Kenderian, M.B., Ch.B., wanted to be a physician. Nothing could blunt his resolve –not even when exploding bombs and trappings of war forced the medical school in his hometown of Baghdad, Iraq, to close briefly. It is with that same determination he conducts Mayo Clinic research into chimeric antigen receptor (CAR) T-cell therapy, a regenerative therapy which unleashes the immune system to attack cancer.

Saad Kenderian, M.B., Ch.B.

“With CAR T, we are on the verge of discovering the potential of immune cells. The results that we are seeing are truly unprecedented, especially in B-cell leukemias and lymphomas. Some patients who really have no other hope are going into complete remission,” says Dr. Kenderian. “Through our research, we are discovering new CAR T products with fewer side effects. These new products may allow us to expand treatment to some blood cancers and solid tumors.”

The key hurdles to bringing CAR T-cell therapy to more patients are cost and access. It’s expensive and there are long waits for clinical trials. Dr. Kenderian’ s team is working collaboratively with Mayo Clinic Center for Regenerative Medicine,  Mayo Clinic Cancer Center  and the Mayo Clinic Department of Laboratory Medicine and Pathology’s Immune Progenitor and Cell Therapeutics Laboratory (IMPACT) lab to manufacture the cancer fighting cells in house and then ramp up production. Currently, Mayo uses commercial grade CAR T-cells engineered by an outside company.

“Making CAR T-cells in house could address issues of cost, access and innovation,” says Dr. Kenderian. “We can make the cells at a fraction of the cost, and we can increase production on our own timeline to increase availability and access to clinical trials. If an individual CAR T doesn’t work for a patient, we can go back and manufacture it according to each patient’s individual needs.”

Mayo
Clinic Center for Individualized Medicine
supports research into new CAR T
products.

Fighting cancer with
genetically engineered cells

CAR T-cell therapy seeks to harness the power of the immune
system by genetically modifying cells, equipping them with power to kill cancer.
These synthetic cells act like a living drug that uses the body’s defense system
to fight disease.

“This is a prime example of regenerative immune therapy.
Immune system T-cells are taken from each patient and engineered with an
artificial protein that supercharges them to recognize and attack cancer. A
large number of these cells are then injected back into the body. It’s a
therapy shaped to each patient,” Dr. Kenderian says.

CAR T-cell therapy may be used on lymphoma and leukemia patients whose cancer has returned twice and no longer responds to standard therapy.

Fascination with the
immune system

Part of Dr. Kenderian’s dream was to practice medicine in the United States. He never envisioned his career would put him on a circuitous path to harnessing the body’s ability to restore form and function.

 After completing his
residency at Michigan State University McLaren Hospital, he came to Mayo
Clinic
for a fellowship in hematology and oncology. It was during that time
he grew fascinated with the power of the immune system and the potential that a
patient’s body could fight disease.

“Tapping the immune system is perhaps one of the only
therapeutic strategies that we can talk about as a potential cure (for cancer),”
he says.

As part of his fellowship, Dr. Kenderian studied under the
pioneers of CAR T-cell therapy at the University of Pennsylvania. He returned in
2016 to help establish the CAR T therapy program at Mayo Clinic.

Mayo Clinic is a
leader in advancing CAR T-cell therapy

Mayo Clinic, which specializes in treating rare and complex
conditions, is one of a select few medical centers in the United States to
offer CAR T-cell therapy in a clinical setting. Dr. Kenderian says research is
advancing this innovative treatment in the following ways:

  • The number of clinical trials involving CAR
    T-cell therapy has doubled in the past year.
  • There are two newly approved drug options for
    leukemia and lymphoma; a third product is expected to clear U.S. Food and Drug
    approval in early 2020.
  • Biomanufacturing of CAR T products is rapidly
    increasing.

Dr. Kenderian says there is still progress to be made in
increasing access and in getting insurance companies to pay. The collaborative
approach to scaling up CAR T cell manufacturing at Mayo, he believes, is an
important step toward solving those challenges.

###

Tue, Aug 6 9:00am · Mayo Clinic Startup Earns World Economic Forum Award

With the promise of potential lifesaving treatments like chimeric
antigen receptor (CAR) T-Cell therapy
comes complex challenges. For instance:
how can we be sure the right cells are going to the right patient? How can we communicate
problems with manufacturing that would affect a patient’s treatment schedule?

To address those concerns, Mayo Clinic startup company Vineti developed first-of-its-kind software package tracking for cell therapies. The software meticulously monitors quality control during every step of the cell’s journey from extraction to infusion. Vineti’s groundbreaking product captured a World Economic Forum Technology Pioneer Award in the field of health. Given to early- to growth-stage companies, this award recognizes new technologies and innovations poised for significant impact on business and society.

Andrew Danielsen

“Creating new products is an additional way that Mayo Clinic can improve patient care. It’s a way to amplify our staff’s talent in terms of meeting the needs of a large number of patients. A single drug, one diagnostic test or one piece of software could positively affect tens of millions of patients,” says Andrew Danielsen, chair of Mayo Clinic Ventures. “Having one of Mayo Clinic’s startups win this award is a validation of our staff’s work to bring a very innovative product to market.”

Vineti’s software reflects a new era of complex care delivered
at Mayo Clinic. Before CAR T-cell therapy, cell processing was typically done within
the treating institution. For CAR T, cells are shipped to an outside pharmaceutical
company where they are genetically modified with potential power to kill
cancer.

Yi Lin, M.D., Ph.D.

“This adds a new layer of complexity to cell processing that we have not had in the past,” says Yi Lin, M.D., Ph.D., a hematologist who is the chair of the Cell Therapy Cross-Disciplinary Group at Mayo Clinic Cancer Center who collaborated on the Vineti software. “Mayo Clinic is a Center of Excellence in delivering CAR-T therapy. Our team is acutely aware of the impact of innovative software on improving patient care. We are happy to share our expertise with Vineti to enable the optimization of their software that brings together different groups to ensure safe and timely delivery of cells to the right patient.”

Mayo Clinic Cancer Center and the Department of Laboratory Medicine and Pathology  Immune, Progenitor, and Cell Therapeutics Lab (IMPACT) collaborated on the software.  Mayo Clinic Center for Regenerative Medicine provided support. Key innovators are Allan Dietz, Ph.D., Dr.Lin and Jeffrey Winters, M.D.

Allan Dietz, Ph.D.

“This award demonstrates the importance and transformative
nature of cell-based therapies for our patients. It is also a great example of
leadership role of innovation and application that the IMPACT lab and
transfusion medicine is having at Mayo and around the world,” says Dr. Dietz.

Jeffrey Winters, M.D.

“CAR T therapy is a rapidly growing treatment which is
critical for the treatment of a variety of patients who have no other options. The
Vineti software ensures that appropriate quality controls are in place for the
therapies to ensure patient safety. The award recognizes their critical role in
this area,” says Dr. Winters.

The software is also used to track cell processing for a range of other conditions, including rare genetic blood disorders. Cell therapy is being pursued in a wide range of serious disorders, including cardiac and inflammatory conditions.

Vineti began as a collaboration between Mayo Clinic and GE
Ventures. Mayo Clinic has retained an ownership stake in the company. Any revenue
generated is reinvested in Mayo Clinic research and education.

###

About GE Ventures
GE Ventures identifies, scales and accelerates ideas that will help make the world work better. Focused on the areas of software, advanced manufacturing, energy and health care, GE Ventures combines equity investing, new business creation, licensing and technology transfer to deliver an innovation platform designed to drive growth for partners and GE. For more information, visit http://www.geventures.com, or follow on Twitter (@GE_Ventures) and LinkedIn.

About Mayo Clinic Ventures
Mayo Clinic Ventures serves Mayo Clinic by finding partners that can bring Mayo’s inventions and clinical knowledge to the marketplace to improve medicine everywhere. Mayo Clinic Ventures’ mission is straightforward: commercialize Mayo Clinic technologies for the benefit of patients worldwide, while generating revenue to support clinical practice, research and education at Mayo Clinic.

Wed, Jul 3 9:00am · Regenerative Medicine Minnesota: Executing Big Hairy Audacious Goals

The
excitement at the 2019 Regenerative Medicine Minnesota meeting was palpable. Health
care providers, scientists, educators, students, lawmakers and life sciences
entrepreneurs mobilized to celebrate the BHAG—big hairy audacious goals in
transforming health care. The BHAG challenge: develop new solutions and innovations
that establish Minnesota as a world class leader and destination for advancing
regenerative medicine into daily practice. Mayo Clinic hosted this year’s
Regenerative Medicine Minnesota meeting in Rochester.

Regenerative
Medicine Minnesota is a statewide bipartisan initiative aimed at
revolutionizing health care from a focus on treating disease to one of tapping
the body’s ability to heal itself. Regenerative Medicine Minnesota seeks to
build on the synergies of education, technology and research to create this new
landscape in health care.

Saranya Wyles, M.D., Ph.D., is one of many innovators who seized the BHAG challenge. Her “Mission to 2025” proposal is one of the nine Regenerative Medicine Minnesota education grant awards for 2019.

Saranya Wyles, M.D., Ph.D.

“Our
goal is to provide regenerative medicine education to all medical students who
train in Minnesota by 2025,” says Dr. Wyles. “We need to prepare the next-generation
physician-scientists so they can safely advance the latest regenerative innovations
into clinical practice. We also want them to have the fluency and resources to
answer questions as patients learn about and seek regenerative care. ”

Dr.
Wyles’ grant will build on the Mayo Clinic Center for Regenerative Medicine
sponsorship and previous Regenerative Medicine Minnesota funding that provided
resources to establish the first patient-centered regenerative medicine medical
school curriculum. This course has trained more than 200 students to date.

“We highlight
ongoing clinical trials, pre-clinical models, bench-to-bedside translation, procedural
simulations, interactive patient experiences and basic science lectures,” says Dr.
Wyles. “The Regenerative Medicine Minnesota grant enables us to attract and
further retain medical trainees in this emerging field by providing travel
awards and research scholarships for summer internships in regenerative
sciences laboratories.”

The
Regenerative Medicine Minnesota annual meeting is a time for all innovators to
share their accomplishments and build strategic collaborations to accelerate
them. Regenerative Medicine Minnesota Board Co-Chairs
Andre Terzic, M.D., Ph.D., director
of Mayo Clinic Center for Regenerative Medicine
and Jakub Tolar, M.D., Ph.D., dean of
the Medical School and vice president for Clinical Affairs at the University of
Minnesota, outlined
the initiative’s major achievements. In five years of this legislative
initiative, Regenerative Medicine Minnesota has awarded 161 grants totaling
$21.9 million of dedicated investment. Grants fund education, research and
technology throughout the state.

This
year’s $4.35 million in awards will fund:

  • Eleven
    research grants
  • Nine
    education grants, including six grants to train k-12 students in regenerative
    sciences
  • Eight
    biobusiness development awards

Andre Terzic, M.D., Ph.D.

“Minnesota’s investment in regenerative medicine has led to tangible advancements in regenerative sciences, translation of new knowledge and the rollout of clinical trials to offer patients hope of new, validated regenerative solutions to improve their health,” says Dr. Terzic.

Jakub Tolar, M.D., Ph.D.

“We
are putting Minnesota at the forefront of introducing regenerative therapies
into clinical practice,” adds Dr. Tolar. “Regenerative Medicine
Minnesota has taken a novel approach to reaching these goals, developing a
pipeline that integrates everything from developing new therapies, to
recruiting and retaining the highly trained workforce of the future needed to
administer these therapies, to building the industry’s capacity to produce
them.”

Examples
of the research supported by Regenerative Medicine Minnesota grants at the University
of Minnesota and at Mayo Clinic include:

  • Performing fetal surgery to correct
    underdeveloped lungs before the baby is born.
  • Growing replacement blood vessels
    for coronary artery bypass.
  • Building an artificial liver to
    function until a human donor is located.
  • Developing a 4D printed system to
    guide delivery of stem cells: where, how, as what and when to deploy.

Three legislators who’ve been strong advocates,
namely — Rep. Tony Albright, R- Prior Lake, Sen.
Richard Cohen
D- St. Paul, and Senator
David Senjem
R-Rochester — appeared on a
legislative panel at the meeting where they affirmed their support and
direction of Regenerative Medicine Minnesota. With that support, the BHAG — big hairy
audacious goals — may
one day become reality in daily patient care.

Dr. Terzic is the Michael S. and Mary Sue Shannon Director, Mayo
Clinic Center for Regenerative Medicine, and Marriott Family Professor in
Cardiovascular Diseases Research.

Dr. Tolar is the Dean of the University of Minnesota Medical School and a Distinguished McKnight Professor in the Department of Pediatrics, Blood and Marrow Transplantation.

Grantees are recognized at the Regenerative Medicine Minnesota annual meeting

Watch a video overview of the 2019 Regenerative Medicine Minnesota grants

###

Tue, Jun 18 1:39pm · 6 "firsts" in advancing regenerative medicine toward patient care

A
statewide bipartisan initiative is transforming health care from a focus on
treating disease to one of tapping the body’s ability to heal itself. Regenerative
Medicine Minnesota

is a legislative initiative aimed at improving health by advancing regenerative
medicine in research, technology, education and patient care across the state.

Minnesotans
statewide struggle with chronic conditions such as diabetes, heart disease and
arthritis that reduce their quality of life and cost the health care system
millions of dollars. Regenerative medicine focuses on using the body’s ability
to heal itself — replacing, repairing, and restoring damaged or missing organs
and tissues to health. There is a critical need to ensure that Minnesotans have
access to safe and effective treatments.

Every
June, scientists, physicians, educators and other health care providers who
have received one of the 161 grants awarded through this initiative, meet to
share their cutting-edge work and find strategic collaborations to accelerate
it. At the 2019 Regenerative Medicine Minnesota annual meeting in Rochester,
co-chairs Andre Terzic, M.D., Ph.D., director of Mayo
Clinic Center for Regenerative Medicine
and Jakub Tolar, M.D., Ph.D., dean of the Medical School and vice
president for Clinical Affairs at the University of Minnesota, will highlight
the effects  Regenerative
Medicine Minnesota

will have on the state. This year’s annual meeting will be held on Monday, June
17, in Rochester.

Andre Terzic, M.D., Ph.D.

“Regenerative
Medicine Minnesota is laying the platform on which education, industry and
medical science are coming together to build the health care of the future.
Minnesota is becoming recognized as the Silicon Valley of regenerative
medicine,” says Dr. Terzic. “This investment has led to tangible
advancements in regenerative sciences, translation of new knowledge and the
rollout of clinical trials to offer patients hope of new regenerative solutions
to improve their health.”

Jakub Tolar, M.D., Ph.D.

“We
are putting Minnesota at the forefront of introducing regenerative therapies
into clinical practice,” adds Dr. Tolar. “Regenerative Medicine
Minnesota has taken a novel approach to reaching these goals, developing a
pipeline that integrates everything from developing new therapies, to
recruiting and retaining the highly trained workforce of the future needed to
administer these therapies, to building the industry’s capacity to produce
them.”

Regenerative
Medicine Minnesota awards $4.35 million in grants every year. Funding is open
to Minnesota-based institutions. Since its inception in 2014, Regenerative
Medicine Minnesota has awarded 161 grants totaling $21.9 million.

Dr.
Tolar and Dr. Terzic noted six examples of how this grant-funded research may
one day transform clinical practice:

  • Performing fetal surgery to correct underdeveloped lungs

A Regenerative Medicine Minnesota grant is funding a clinical trial for
prenatal surgery to promote lung growth before babies are born. Rodrigo Ruano, M.D., Ph.D., a Mayo Clinic obstetrician and gynecologist, has performed
four in utero surgeries on fetuses with a life-threatening disorder known as
pulmonary hypoplasia as part of a clinical trial. This condition is caused by
congenital diaphragmatic hernia in which fetal lungs are too small for babies
to breathe on their own. The grant fosters the development of regenerative
approaches to improve lung development and survival.

  • Growing replacement blood vessels for patients in need of coronary artery bypass

A patient with a severe heart
blockage who needs a second bypass may no longer have a spare vessel that can
be used for the surgery, and tissue-engineered arteries lack the cellular lining
needed to reduce the risk of blood clots. Professor Robert Tranquillo, Ph.D., a University of Minnesota biomedical
engineer in the College of Science and Engineering, is developing a high-speed
method of using a patient’s stem cells to “seed” the surface of a bioengineered
blood vessel developed in his lab that creates a cell lining and quickly makes it
ready for surgical implantation.

  • Building a new liver to function like a human organ

A liver transplant can mean the
difference between life and death for some patients. Often, patients die before
they find a suitable donor. With a research grant from Regenerative Medicine Minnesota, Scott Nyberg, M.D., Ph.D., a Mayo Clinic transplantation
surgeon, is building an artificial liver and studying whether it could function
similar to a kidney dialysis machine, performing critical bodily functions
while the liver regenerates. Dr. Nyberg will study if the artificial liver can bridge
the gap until a donor liver becomes available or if it could help the patient avoid
the need for a transplant altogether.

  • Assisting transplant recovery

Shernan Holtan, M.D., a University of
Minnesota hematologist and oncologist, treats patients with leukemias and other
cancers for which bone marrow transplant is a common and effective therapy. Her
research focuses on recovery from transplants, particularly when the donor is a
less-than-perfect match. A common complication of bone marrow transplant is
graft-versus-host disease, in which the immune system from the donor can attack
the patient’s tissues, particularly skin and mucus membranes. Dr. Holtan’s research
examines how to speed up the recovery of tissue damage from these immune
attacks.

  •  Researching regenerative therapies for spinal cord injuries

A Regenerative Medicine Minnesota grant funded an early study by Mohamad Bydon, M.D., a Mayo Clinic neurologic surgeon, on
the safety and feasibility of stem cell injections to treat spinal cord injury.
The stem cells are derived from a patient’s fat cells and injected into
patients through a procedure known as a lumbar puncture. Investigators
collected cerebrospinal fluid on all the patients as part of this clinical
trial to discover different biological markers of spinal cord injury amenable
for repair. New biological markers are important because they can help identify
the critical processes that lead to spinal cord injury at a cellular level and
potentially can lead to new regenerative therapies.

  • Engineering cells to regenerate heart tissue

This Regenerative Medicine Minnesota grant seeks to advance research into
whether stem cells can repair damaged heart tissue. The research of Associate Professor Michael McAlpine, Ph.D., a University of Minnesota mechanical
engineer in the College of Science and Engineeringaims to take a significant step forward by creating a 4D printed
system to deliver the biochemicals that tell stem cells where to go, when to
grow, and what kind of cells to develop into so that they can regenerate
specific kinds of tissues in the heart in an orchestrated manner.

“Regenerative Medicine Minnesota is one of the most
important investments Minnesota has made in the health care of our citizens. In
just five years, new discoveries are moving from the laboratory to clinical
trials where they will be validated as new therapies to address the growing
epidemic of chronic diseases,” says  Rep. Tony Albright, R-Prior Lake, a sponsor of the legislation that funds
Regenerative Medicine Minnesota.

“Regenerative
Medicine Minnesota has not only met, but it has exceeded the expectations we’ve
had for this initiative. Minnesota is leading the way in moving regenerative
medicine into the practice. This initiative bolsters Minnesota’s reputation as
a global leader in regenerative health care and innovator in the medical device
industry,” says Sen. Richard Cohen,  D-St. Paul, chair of
the conference committee that passed the funding proposal for Regenerative
Medicine Minnesota.

Additional
validation will be needed to move regenerative therapies and technologies
toward Food and Drug Administration approval for daily standard of care in
clinical practice.

Dr. Terzic is the Michael S. and Mary Sue Shannon Director, Mayo
Clinic Center for Regenerative Medicine, and Marriott Family Professor in
Cardiovascular Diseases Research.

Dr. Tolar is the Dean of
the University of Minnesota Medical School and a Distinguished McKnight
Professor in the Department of Pediatrics, Blood and Marrow Transplantation.

###

About
the University of Minnesota Medical School

The University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and educating the next generation of physicians. Its graduates and faculty produce high-impact biomedical research and advance the practice of medicine. Learn how the University of Minnesota is innovating all aspects of medicine by visiting the University of Minnesota website.

About Minnesota Stem Cell Institute

The Minnesota Stem Cell
Institute aims to use stem cell biology to change the practice of medicine
through discovery, education and translation. Established in 1999, the Stem
Cell Institute within the University of Minnesota Medical School is the first
interdisciplinary institute in the U.S. dedicated to stem cell research. Learn more on the Minnesota
Stem Cell Institute website
.

About Mayo Clinic Center for
Regenerative Medicine

Mayo Clinic Center for Regenerative Medicine seeks to integrate, develop and deploy new regenerative medicine products and services that continually differentiate Mayo’s practice to draw patients from around the world for complex care. Learn more on the Mayo Clinic Center for Regenerative Medicine website.

About Regenerative
Medicine Minnesota

Regenerative Medicine Minnesota aims to improve the health of Minnesotans by advancing regenerative medicine research, education, and industry and care delivery to patients. Regenerative Medicine Minnesota leverages the strengths of Minnesota institutions to position the state at the forefront of regenerative medicine.

About Mayo Clinic

Mayo Clinic is a nonprofit
organization committed to clinical practice, education and research, providing
expert, comprehensive care to everyone who needs healing. Learn more about
Mayo Clinic
. Visit the Mayo Clinic News Network.

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