Posts (21)

16 hours ago · Seeking a regenerative therapy for chronic dry mouth

Mayo Clinic researchers are seeking a regenerative therapy for a vexing problem, particularly among cancer patients. How can medical providers treat a condition in which the mouth is so parched that it has an incessant feeling of a cotton lining? Xerostomia, also known as chronic dry mouth, is an agonizing side effect of injury to the salivary glands. While it is most common after radiation treatment for head and neck cancer, it also afflicts people with diabetes, stroke, Alzheimer’s disease and HIV/AIDS.

Jeffrey Janus, M.D.

“Dry mouth is something that when you have a life threatening illness, at first may not seem like a big deal. However, this condition can extend long after radiation treatments are complete. It’s probably the top concern I have from head and neck cancer patients. Unfortunately, there aren’t many therapeutics available commercially for these patients,” says Jeffrey Janus, M.D., an Ear, Nose and Throat specialist at Mayo Clinic in Florida.

Currently there is only supportive care —  no cure — for the decrease in saliva that comes from xerostomia. Besides being uncomfortable, chronic dry mouth can lead to difficulties with chewing, tasting, speaking and swallowing. It can also cause tooth decay.

Mayo Clinic Center for Regenerative Medicine, Department of Laboratory Medicine and Pathology and Department of Otolaryngology are collaborating on ways to address the unmet needs of these patients.

The question investigators are seeking to answer is whether the body’s healing abilities could be unleashed to restore natural lubrication of salivary glands. The research will focus on the regenerative abilities of epithelial cells found within many glands in the body, including salivary, mammary and prostate glands. They hope to discover whether epithelial cells could be tapped to regenerate salivary gland tissue to produce natural saliva.

Building on existing research

Previous studies showing epithelial cells purified from mammary glands could regenerate functionally-intact mammary glands piqued the interest of the research team.  Could the same concept be applied to heal and restore saliva in salivary glands? Their research will build on this existing body of knowledge.

Nagarajan Kannan, Ph.D.

“In many ways salivary glands resemble mammary glands. As early as 2006, it was shown that a single transplantable mammary cell could regenerate highly complex lactational structure. That was the genesis of the concept that glands represent epithelial stem cells and that we might be able to harness these rare cells for treatment of dry mouth,” says Nagarajan Kannan, Ph.D., a scientist with the Department of Laboratory Medicine and Pathology and head of the Stem Cell and Cancer Biology Lab at Mayo Clinic.

To validate this theory, the team has identified a few hurdles to overcome that could stall the research.

First, they need robust human tissue samples to test their theory. They’ve planned to establish a biobank of the three different types of human salivary glands with samples from consenting men and women. Second, they are developing robust methods to isolate and study epithelial cells from salivary glands. Third, they need a model in which to investigate whether those cells could regenerate human salivary tissue. To address this issue, they will study epithelial cells in immune-deficient mice that have been biologically engineered to mimic injured human salivary glands.

“Using this model, we can now start testing how the salivary cells permanently engraft and regenerate into salivary structure and restore saliva. Our model measures how saliva production drops and holds at a decreased level. It is the best model available for studying how human salivary samples perform over time,” says Dr. Kannan.

No specific date has been set for advancing this concept into human clinical trials. However, Dr. Kannan and Dr. Janus are hoping the preclinical studies will lay the foundation for early safety studies within the next year or two.

“I’m hopeful that if we can show this is safe and effective, we can immediately transition into using this regenerative procedure using silo endoscopy, which is like endoscopy of the salivary glands, to implant these cells in early clinical trials,” says Dr. Janus.

Accelerating the findings toward clinical practice is a priority. The team will not only work across departments at Mayo Clinic, but will also collaborate with experts outside of Mayo Clinic to move the research forward as quickly as possible.

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Thu, May 21 8:30am · Preparing health care leaders of tomorrow for a new era of regenerative care

To accelerate regenerative medicine toward daily clinical care, the next generation of physician-scientists need to master expertise in this dynamic and emerging field. Mayo Clinic is among a select group of academic medical centers developing advanced curricula in regenerative sciences. The Center for Regenerative Medicine is on the forefront, engaging with the Mayo Clinic Graduate School of Biomedical Sciences to prepare students for a new era of care focused on rebuilding and restoring health.

Richard Hayden, M.D.

“Regenerative sciences is becoming a very popular field of study among our students,” says Deputy Director of Education for the Mayo Clinic Center for Regenerative Medicine, Richard Hayden, M.D. “This year, nearly a quarter of all students coming into the Ph.D. program in the Mayo Clinic Graduate School of Biomedical Sciences have chosen a regenerative medicine topic for their degree. The more next generation experts with advanced training, the stronger Mayo Clinic and the health care profession will be in this emerging specialty. That ultimately benefits our patients.”

The Center for Regenerative Medicine currently supports more than 20 students in its Regenerative Sciences Training Program, which offers a doctorate degree in biomedical sciences with an emphasis in regenerative sciences and their track of choice.

“One of our responsibilities with a new, exciting field is to temper it with reality. We try to be the responsible educators who winnow the hype from hope. Future health care leaders are getting an optimistic, but realistic introduction into regenerative sciences,” says Dr. Hayden.

Read the story of one student’s journey through the Regenerative Sciences Training Program and how she is spreading her enthusiasm for this topic with future classmates.

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Thu, May 14 8:30am · Research grants aim to advance regenerative medicine toward the practice

Reprogramming human cells to correct blood disorders such as sickle cell disease, activation of a regenerative pathway to treat liver failure and strategies for skeletal regeneration in patients with brittle bone disease are examples of Mayo Clinic research to be funded through new grants from Regenerative Medicine Minnesota. 

Regenerative Medicine Minnesota, a statewide bipartisan initiative, seeks to advance regenerative science and build the health care of the future. Regenerative Medicine Minnesota awards $4.35 million in grants every year with emphasis on innovation across the regenerative medicine spectrum. The initiative seeks to transform the focus of medicine from treating disease to building health in order to provide Minnesotans with safe new options for their health care. Since its inception in 2014, Regenerative Medicine Minnesota has awarded more than 170 grants totaling $26 million.

In the latest funding cycle, Regenerative Medicine Minnesota awarded seven discovery and translational science awards to Mayo Clinic researchers.

Discovery Science Awards:

Patricia Devaux,
Ph.D.

Patricia Devaux, Ph.D., $249,998 for Concurrent Gene Editing and Reprogramming of Sickle Cell Disease Fibroblasts using Dual Measles Virus Vectors

This research will test a new technology based on the vaccine strain of the Measles virus to determine if it can reprogram human cells to correct genetic defects that lead to blood disorders such as sickle cell disease.

David Deyle, M.D.

David  Deyle, M.D., $250,000 for Treating Osteogenesis Imperfecta by Inhibiting the PRC2 Complex
The goal of this research is to develop new ways of increasing bone formation for osteogenesis imperfecta, also known as brittle bone disease, using small molecules to inhibit the epigenetic regulator, PCR2.

Dan Dragomir-Daescu, Ph.D.

Dan  Dragomir-Daescu, Ph.D., $249,112 for Novel Flow Diverter for Hemorrhage Control Using Innovative Magnetic Nanotechnology

The study team will test in pig models the use of novel magnetic technologies, including vascular stent-grafts and bioengineered endothelial cells (cells that line the blood vessels), to see if they can be used together to control hemorrhage and rapidly heal vessels.”

Martin Rodriguez-Porcel, M.D.

Martin Rodriguez-Porcel, M.D., $250,000 for Understanding the Interaction of Stem Cells and Scaffolds with Host Tissue: Implications of Regenerative Medicine

This study aims to develop a better understanding of the interaction between transplanted stem cells and human tissue.  Specifically, this research seeks to answer whether delivery of biomatrix containing certain chemicals can help transplanted stem cells survive and function in the human body.

Rory Smoot, M.D.

Rory Smoot, M.D., $250,000 for Activating the Hipp Pathway Effector YAP to Augment Liver Regeneration

The goal of this research is to improve liver function in patients with liver failure. The research team will test whether a specific drug treatment can activate a regenerative pathway and speed liver regeneration.

Translational Science Awards:

Terry Burns, M.D., Ph.D., $250,000 for Human Glial Progrenitor Cells for Radiation-Induced Brain Injury

Terry Burns, M.D., Ph.D.

This study seeks new solutions for memory and functional impairment caused by radiation to kill brain tumors. Researchers will test in brain models the safety of transplanted stem cells capable of replacing myelin.  Myelin is a substance that coats and protects nerves and improves neurological function.

Steven Moran, M.D.

Steven Moran, M.D., $250,000 for Regenerative Strategy for Volumetric Muscle Loss and Functional Recovery

This study seeks new regenerative therapeutics for restoring muscle volume and muscle function after traumatic injury or surgery.

Regenerative Medicine Minnesota awarded 13 grants statewide out of 64 applicants in 2020 to advance clinical trials, discovery science, translational science and biobusiness. Funding awarded in 2020 will run through 2022. Regenerative Medicine Minnesota grants are open to all Minnesota-based institutions.

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Thu, May 7 8:30am · A discovery step toward cell replacement therapy for diabetes

In what could be a step toward cell replacement therapy for diabetes, Mayo Clinic researchers have discovered how to manufacture cells capable of generating a hormone that regulates low blood sugar. Quinn Peterson, Ph.D. and his team have developed a new method of mass producing a cell product containing the hormone glucagon that is capable of protecting against hypoglycemia in animal models. Dr. Peterson’s research is published in Nature Communications.

Quinn Peterson, Ph.D.

“We now have the ability to manufacture large quantities of an important cell type that is necessary to prevent hypoglycemia and regulate blood glucose in patients with diabetes. Generating pancreatic cell types from renewable sources holds promise for cell replacement therapies for diabetes,” says Dr. Peterson, principal investigator.

Alpha cells in the pancreas produce glucagon, which is released to correct low blood sugar levels. However, in diabetes these alpha cells become dysfunctional, leaving patients susceptible to hypoglycemia (low blood sugar). Left untreated, hypoglycemia can cause a patient to fall into a coma and die.

Biomanufacturing cells

The new cell product is human tissue derived from pluripotent stem cells, which have the capacity to self-renew and convert into alpha cells containing glucagon. When transplanted into animals, Dr. Peterson’s team discovered, these cells defended against hypoglycemia. Researchers hope someday these biomanufactured cells could restore cell function lost to diabetes.

With capabilities from the Center for Regenerative Medicine, including the Center’s Bio trust and the Center’s Process Development Laboratory, Mayo Clinic has the ability to ramp up large scale manufacturing of cells right on site. Quality and regulatory teams are working on new standard operating procedures that provide the foundation for current Good Manufacturing Practices needed to comply with Food and Drug Administration regulations. That could eventually pave the way for clinical trials geared toward exploring the safety and effectiveness of manufactured cells as a treatment for Type 1 diabetes.

“If successfully introduced into clinical use, these cells could dramatically change patient care for diabetes.  Rather than rely on routine blood checks to prevent hypoglycemia and emergency room interventions to treat severe hypoglycemia, in the future, patients may be able to receive a transplant of living medicine that will both monitor blood glucose levels and administer corrective doses of glucagon,” says Dr. Peterson.

Dr. Peterson estimates that the first test of these cells in human clinical trials could take place by 2022.

This work was supported in part by benefactor gifts to the Mayo Clinic Center for Regenerative Medicine, including the Stephen and Barbara Slaggie Family, J.W. Kieckhefer Foundation and the Khalifa Bin Zayed Al Nahyan Foundation. Colleagues at Harvard University and University of Gothenburg participated in this study. 

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Thu, Apr 30 8:30am · Regenerative approaches could foster healing from COVID-19

Regenerative Medicine aims not only to repair or restore the function of cells, tissues or organs, but also the whole person. The latter is particularly important amid the COVID-19 pandemic. Regenerative approaches draw on the body’s natural abilities to heal, focus on establishing the healing environments and building new, healthy ways of functioning. These aspects of regenerative medicine may nurture healing in people who’ve contracted the virus, those who treat it and the broader community whose lives have suddenly been changed by the pandemic.

Creating safe, trusting environments

When people are diagnosed with COVID-19, their illness may go beyond physical afflictions to a breakdown of the mind and spirit. Some Coronavirus patients are immediately isolated, separating them from the people they love. That may trigger confusion, fear, anxiety and mistrust.

In a normal health care environment, patients might be soothed by welcoming faces and warm touches of medical professionals. But in the new world of a virus to which no one is immune, caregivers must wear personal protective equipment for their own safety. The face masks that allow patient and clinician to come together safely may also be a barrier that increases isolation and fear.

Victor Montori, M.D.

“It creates a new population of people who are traumatized,” says Victor Montori, M.D., an endocrinologist at Mayo Clinic and expert leader for the Mayo Clinic Center for Regenerative Medicine. “This trauma is a response to the difficult and unbearable aspects of COVID-19. It manifests itself as emotional and physical responses. In addition to fostering conditions to prevent trauma, the regenerative approach to healing in this case might mean that as people recover from COVID, they go on to receive additional care from psychologists and social workers that would help them build trust to overcome their trauma.”

Health care professionals who are on the forefront of care may themselves suffer trauma, particularly if they witness death, see colleagues become ill or have to make difficult decisions about prioritizing care.

Dr. Montori says creating a safe, trusting environment is a good antidote to trauma.  He suggests an effective platform for healing may be trauma-informed care, a way to prevent and care for people with post-traumatic stress disorder. Trauma-informed care creates a safe environment in which trauma is noticed and a caring response developed that fosters recovery. The emphasis for caregivers is on organizational safety, trustworthiness, cultural sensitivity and collaboration.

For the patient, trauma-informed care seeks to build coping skills and foster resiliency through:

  • Managing emotions
  • Connecting with others
  • Finding hope, purpose and meaning

“To build back health, they’ll need to rehab their muscles and ability to breathe. Equally important is to regenerate the psyche and the way they trust and feel safe in the world.  Teamwork across clinical disciplines and collaboration with community partners is necessary, therefore, to work with affected patients and clinicians, so they can be supported in their healing,” says Dr. Montori.

Tapping the human mind to heal

Emotional trauma may extend beyond patients suffering with COVID-19 and those on the front lines of treating it, according to Craig Sawchuk, Ph.D., L.P., chair of Mayo Clinic Division of Integrated Behavioral Health. Fear, anxiety and stress also may be prevalent in otherwise healthy people who are overwhelmed by the societal and economic fallout of the pandemic. Psychological healing may be needed among people who fear contracting COVID-19 as well as those experiencing social isolation, job loss or financial pressures.

Craig Sawchuk, Ph.D., L.P.

“The amount of uncertainty related to COVID-19 is unprecedented,” says Dr. Sawchuk. “There has been a complete disruption of day-to-day routines. No one is certain how long it is going to last. We see stress-related problems like sleep disruption, fatigue, physical tension, irritability and worry.”  

One key way to foster psychological healing, Dr. Sawchuk says, is by taking charge of things you can control and letting go of things you can’t.

“It is important to come to a level of acceptance with the situation. That doesn’t mean you have to be OK with it,” says Dr. Sawchuk. “But, we must be aware some people will have trouble and get stuck in conditions similar to post traumatic stress disorder or significant depression. They may need ongoing treatment.”

Dr. Sawchuk recommends several pathways to healing:

  • Limiting exposure to COVID-19 related news.
  • Finding support from family, faith and friends.
  • Developing a structured daily routine that includes proper nutrition, exercise and sleep.
  • Exploring self-help resources such as mental health apps that offer coaching for stress management, worry management, positive attitude and goal setting. Psyberguide.com is a free service that provides ratings of mental health apps.
  • Seeking face-to-face counseling, including behavioral therapy and other coping strategies.
  • Making an appointment for psychiatric evaluation or medication management.

In a world that has changed dramatically in just three to six weeks of time, healing mind, body and spirit may take time.

“It’s not like a light switch in which we can instantly turn back on the economy or return to our normal social routine. It’s probably going to be more like a gradual dimmer switch. For a while, people are going to feel like they are living life walking in a minefield. They’re likely to be extra cautious about reclaiming their usual activities,” Dr. Sawchuk says.

Rebuilding health

The regenerative medicine notion of building something new to restore health may also be applied to COVID-19 healing.

Ian Hargraves, Ph.D.

“Already, we see a lot of building and creating in the way that people live with COVID-19,” according to Ian Hargraves, Ph.D., a scientist and author of a regenerative medicine position paper. “People are creating new types of social interactions based on social distancing, and they are remaking schooling through online learning. They are redefining work and family life. People are making masks and creating new senses of who they are and what their world is.”

Those recovering from the trauma of COVID-19 may not be able to go back to the way things were before the pandemic, Dr. Hargraves says. For example, they may need to continue the practice of social distancing or may need to take their temperature daily. Although the virus was thrust upon hundreds of thousands of people, those who care for people with COVID-19 can help with healing by supporting people as they rebuild their lives, relationships and outlook, he adds.

Dr. Sawchuk predicts that personal and community healing will eventually come when COVID-19 infections, hospitalizations and deaths subside. Until that time, a regenerative approach of creating an environment of trust to ease trauma, tapping the human psyche for healing and focusing on creating something new may be the catalyst for recovery and preparation for a post-COVID-19 world.

The Mayo Clinic Center for Regenerative Medicine supports programs and practices that transform the focus of health care from treating disease to one of restoring health and healing.

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Thu, Apr 23 8:30am · Training the workforce of the future in CAR T-cell therapy

Mayo Clinic is equipping the next generation of physician-scientists with knowledge to bring chimeric antigenic receptor (CAR) T-cell therapy to more patients. One of the first medical centers to offer CAR T, Mayo Clinic is sharing its unique knowledge of this regenerative immunotherapy in a first-of-its kind graduate mini course offered through the Mayo Clinic Graduate School of Biomedical Sciences. This educational endeavor is integral to a growing emphasis on regenerative medicine intense curricula at Mayo Clinic.

Saad Kenderian, M.B., Ch.B.

“This is an emerging field that is rapidly changing. To keep up with the latest innovations, comprehensive training is needed for basic scientists, biomedical engineers, translational investigators and clinician investigators to ensure that experts from these distinct disciplines are able to work together to harness new discoveries and effectively bring them to the clinic in an efficient and timely manner,” says Saad Kenderian, M.B, Ch.B., who teaches the course.

CAR T-cell therapy is a regenerative treatment that unleashes the body’s immune system to attack cancer, especially in B-cell leukemias and lymphomas.

With support from the Mayo Clinic Center for Regenerative Medicine and the Department of Immunology, the mini course “Regenerative T-Cell Immunology in the Treatment of Cancer” is designed to inspire scientists, medical students, clinicians, residents and fellows to advance the discovery, translation and application of CAR T-cell therapy. 

The topics include:

  • Basics of tumor immunology
  • Adoptive cell therapy
  • Laboratory skills
  • How to write grants to obtain research funding
  • Overview of the regulatory environment
  • Workshops on flow cytometry, tumor models and cGMP CAR T-cell generation

“Clinical translation requires expertise in translational science, Food and Drug Administration regulation and good manufacturing practices. Successful delivery incorporates providers in multiple medical specialties, including oncology, critical care, neurology and laboratory medicine,” says Dr. Kenderian.

Expanding CAR T-cell therapy at Mayo Clinic

The course is offered  as Mayo Clinic division of Hematology/Medical Oncology, the Center for Regenerative Medicine and the Cancer Center are working together to develop and expand new CAR T and other cancer immunotherapies. Mayo Clinic in Florida has hired a new person to direct the cancer immunotherapies program.

Scientists at Mayo Clinic are preparing to biomanufacture the CAR T-cells in house. Currently CAR T-cells are sent to an outside lab where they are genetically modified with the power to go on search and destroy missions to kill cancer. These synthetic cells act like a living drug that taps the body’s defense system to fight disease.

“Manufacturing CAR T-cells right at Mayo Clinic will make them more accessible, less expensive and more individualized to the patient. It can be done in a week instead of the three to four weeks it takes at an outside lab. That’s especially important for patients with aggressive cancers who need immediate treatment to stop the progression of their disease,” says Dr. Kenderian.

The CAR T mini course will be held online May 5-7 and is open to scientists, graduate students, medical students, clinicians, residents and fellows. There are special tracks for pharmacists, nurses and physician assistants. Doctoral students can earn three credits from the Graduate School of Biomedical Sciences and clinicians can earn continuing medical education credits.

The course is open to medical providers outside of Mayo Clinic.The course was first introduced in 2017, and surveys showed it increased interest and skills among the students. Read an analysis of the course here. Those interested in attending must have Dr. Kenderian sign a late registration form and email that form to comregistrar@mayo.edu

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Thu, Apr 16 8:30am · Focus on women's health: regenerative approaches to stress and fecal incontinence

Mayo Clinic is taking a regenerative approach to women’s healthcare to provide new therapeutic options for common conditions that standard treatments don’t fully address. One key area of focus is pelvic floor injury that leads to stress incontinence, a widespread and often embarrassing problem affecting some 18 million women, according to the National Association for Continence.

With support from the Mayo Clinic Center for Regenerative Medicine, researchers are probing ways to direct cells to grow new skeletal muscle and restore the body’s ability to control the release of urine and stool.

Emanuel Trabuco, M.D.

“These are clearly embarrassing situations for our patients, and I believe that often there’s an under representation of women who deal with this. For every patient I have in my office, there’s probably another 5 or 10 who are not coming in because she’s embarrassed to talk about it,” says Emanuel Trabuco, M.D., a urogynecologist at Mayo Clinic.

Life events unique to women such as childbirth, pregnancy and menopause may injure and weaken sphincter muscles surrounding the urethra — the tube through which urine passes out of the body. That can lead to involuntary leaking of urine, particularly when a woman laughs, coughs or sneezes.

Since the late 1990’s, the standard surgical treatment for stress incontinence has been a polypropylene mesh sling implant that supports the urethra. However, even with the sling, some women still experience involuntary leakage. Mayo Clinic researchers are seeking regenerative solutions that would bolster standard treatments and provide new therapeutic choices.

The research

Mayo Clinic researchers are investigating the use of purified exosomal products (PEP) to grow skeletal muscles that could strengthen the pelvic floor. PEP is a cell-free product developed at Mayo Clinic that can be used right at the hospital without the need to grow cells in a lab. PEP contains molecules that direct stem cells to grow and make new muscle, thereby repairing areas of injury. Researchers discovered that PEP could repair the injured urethral sphincter muscle and re-establish pre-injury pressures using an animal model. The histological evaluation showed new muscle tissue and less inflammation at the site of the injury site. They hope that these findings could be translated into a new treatment to control stress incontinence in humans.

“If this works, this would be the first time we’ve been able to improve muscle function as an alternative to treating stress incontinence,” says Dr. Trabuco. “In the past, the only incontinence treatments have been procedures like a sling that establish support underneath the urethra. This would also provide an alternative treatment for women who had a sling but still suffer from slight urinary leakage.”

Fecal incontinence

During child birth, up to 25% of women injure the anal sphincter, a group of muscles that maintains fecal continence when contracted. Despite suture repair of the anal sphincter, some women fail to restore muscle connections and function due to infections or scarring. This results in fecal incontinence symptoms. 

“Studies show up to 88% of women still had defects in the anal sphincter after the suture repair.  It seems that the anal sphincter repair at the time of delivery is not working for a lot of women.  As a result, many patients seek help for fecal incontinence many years after delivery,” says Dr. Trabuco.

Ideally, the optimal time to re-establish function is at the time of delivery. In pilot studies, researchers repaired the anal sphincter with suture while adding PEP to the repair. Similar to their studies on urinary incontinence, researchers showed that sphincter repair with PEP improved muscle healing and strength. These findings gives them hope that new treatment options for fecal incontinence may be on the horizon.

Researchers are seeking to test the purified exosomal products in humans in a phase I clinical trial in humans before then end of 2020.

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The Center for Regenerative Medicine recognizes Michael S. and Mary Sue Shannon for their generosity and support in advancing regenerative women’s health research.

Thu, Apr 9 9:00am · Transforming the future of organ transplantation

Mayo Clinic is turning to regenerative medicine to address a critical shortage of donor organs. Physicians and scientists are studying 3D printing, tissue engineering and cellular and cell free therapies as ways to build new organs or restore the health of organs that previously were discarded. The ultimate goal is to provide a transplant for everyone with organ failure who needs one. 

More than 110,000 Americans are currently on the organ donor waiting list, and a new name is added every 10 minutes, according to the National Foundation for Transplants, which estimates that 20 people die every day before a suitable match is found.

With support from the Mayo Clinic Center for Regenerative Medicine, physicians and scientists at Mayo Clinic’s Florida campus will lead Transforming Transplant, a translational science initiative to provide new clinical options for patients with organ dysfunction and failure.

The Transforming Transplant initiative seeks to advance research into:

  • Bioengineering new organs that could be used in place of human donors.
  • Exploring the use of stem cells to prevent organ failure.
  • Restoring the health of donor organs that were previously considered too old or medically risky to be transplanted.
  • Preventing the need for transplant by diagnosing disease earlier, when organ function could still be preserved.
  • Eliminating the need for lifelong immunosuppressant measures following transplant.

C. Burcin Tanner, M.D.

“Organ transplantation is often referred to as one of the greatest achievements in the history of medicine. In the last three decades, enormous strides have been made, but there are still unmet needs,” says C. Burcin Taner, M.D., chair, Department of Transplantation, on Mayo Clinic’s Florida campus. “The ultimate goal of this multidisciplinary initiative is to significantly decrease or eliminate organ failure and the number of deaths on the organ transplant wait list,”

This initiative comes as Mayo Clinic, a pioneer and leader in the field, recently reached a milestone of performing its 20,000th organ transplant.

Read more on that story.

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