The major challenge in treating obesity is not just losing weight, but preventing weight from coming back. With a research grant form Regenerative Medicine Minnesota, Ping (Vicky) Chen, Ph.D., Mayo Clinic research associate, is studying a new treatment strategy using gene transfer therapy to safely target brain mechanisms that control hunger and energy output.
Dr. Chen’s previous research in mice found that gene transfer of a well-tolerated liver enzyme could revolutionize clinical treatment of obesity, making it easier for obese patients to lose weight safely and minimize later weight gain. Her pre-clinical research on the mechanism behind weight control will further determine if this approach might succeed in humans. Researchers expect the effects to correlate positively with reduction in ailments such as diabetes, metabolic syndrome and fatty liver disease.
Learn more about Dr. Chen’s research: