March 31, 2017

Knee Deep: Treating Knee Disorders with Regenerative Medicine

By centerforregmedmc

This story was previously published in Mayo Clinic Magazine.

According to a joint project of leading orthopedic societies in the United States, musculoskeletal disorders for work-related injuries account for one half of all days away from work. A decade ago, these conditions cost Americans nearly $1 trillion in health care costs and lost wages. That’s an astounding 7.4 percent of the gross domestic product in the U.S. The problem has only gotten worse since then.

The latest figures from the Centers for Disease Control and Prevention show that from 2000 to 2010 the number of knee replacements nearly doubled. And the United States is just at the beginning of the surge of retiring baby boomers, who are more active than earlier generations of retirees, so it is anticipated that the demand for knee replacement services will climb sharply.

In addition to societal impact, knee conditions can be devastating on an individual level. They cause substantial pain and can dramatically decrease quality of life for anyone at any age — active adolescent athletes who rupture a ligament or damage cartilage; healthy middle-aged adults who incur wear-and-tear disorders; and vibrant retirees who lose independent living and acquire chronic diseases such as diabetes and hypertension because of arthritis. These conditions are incredibly complex, involving bones, muscles, ligaments, tendons and cartilage.

To help people delay or even prevent costly replacements, Mayo Clinic’s Center for Regenerative Medicine is supporting four studies aimed at different parts of the knee.

Mesenchymal Cells

Mayo Clinic has launched the first study in the U.S. to treat knee arthritis with stem cells harvested from fat tissue and grown in a lab. Compared to trials with bone marrow concentrate, this trial will inject millions of purified stem cells into arthritic knees to study the ability of these cells to reduce symptoms and regenerate damaged tissue. Researchers will follow subjects with a variety of measures, including cartilage-sensitive MRI scans. With this information, Mayo researchers will build a foundation for further stem cell research and develop ways to tweak the stem cells in future patients to enhance their healing ability

Gene Therapy

Researchers know that injections of a specific protein — interleukin-1 receptor antagonist protein (IRAP) — will help reduce swelling in the knee joint. Unfortunately, the effect doesn’t last long as the protein is gone within 30 to 60 minutes. However, researchers at Mayo Clinic are developing a gene that produces the protein and are placing it into a virus that can be injected into the knee. With the help of the virus, the gene “infects” the native knee cells so that the body produces the protein for up to a year. Researchers expect to launch a phase I trial within a year.

Platelet-Rich Plasma

Your body is filled with healing cells, growth factors and proteins. To treat knee arthritis, Mayo Clinic researchers are testing platelet-rich plasma, which is rich in all three. The technique starts with a patient’s own blood, and researchers centrifuge it to concentrate the platelets into a small volume of plasma. Platelets contain several growth factors that aid in healing. The enriched plasma is then injected back into the patient to reduce pain and inflammation, improve function and promote healing.

Bone Marrow Concentrate

Similar to platelet-rich plasma, your body contains bone marrow rich in proteins and growth factors. However, bone marrow also contains stem cells, which are powerful cells capable of reducing inflammation, promoting cell division and potentially slowing down arthritis. When concentrated, bone marrow delivers a robust mix of proteins, stem cells, platelets and other cells. The quantity of stem cells available for most bone marrow concentrate procedures is small — approximately 50,000 per injection — but bone marrow concentrate has demonstrated success for improving knee conditions such as arthritis. Mayo Clinic researchers are studying the components of bone marrow concentrate to determine optimal dosing and treatment regimens.


Tags: Bone Marrow Concentrate, gene therapy, knee disorders, Mayo Clinic, mesenchymal cells, News, orthopedic, regenerative medicine, stem cells

I am past patient at Mayo for cancer treatment and thyroid. Now to my knees…right knee had replacement surgery one year ago. A 55 year old cartelidge football tear. Now the left knee…..I have a partial meniscus tear I have been putting up with for about three years. Now planning on surgery at Tria in Minne. to remove. Also shots every 3 or 4 months, otherwise extremely painful. I would like to investigate any alternative solutions that might be available before this removal surgery. I do have a copy of my xray history on this knee approximately one year old. I am 73 years old active and in good shape thanks to modern medicine. I would like to be contacted for review and treatment consideration at your earliest convenience. Thank You….John Fryklund


Hi there. Did you ever get a response and if so what is being done to help you…John

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