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February 9th, 2017

The Case for Stem Cell Treatments for ALS

By Center for Regenerative Medicine

When nerve cells in the brain and the spinal cord stop working normally there is a noticeable change in muscle movement and activity. Motor neurons work with the brain to control muscle movement such as gripping and walking. These activities become increasingly difficult with the onset of amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s disease or motor neuron disease.

There is no effective treatment for ALS. According to the ALS Association, an estimated 20,000 Americans between the ages of 40 and 70 are living with the progressively paralytic disorder. It is still unknown why the symptoms begin to manifest out of the blue. The time frame from the onset of symptoms to the end of life can be as short as three years. For most, the disease is not inherited; only a small percentage of patients carry the genes that are associated with ALS.

One medical approach is to try to keep the nerve cells alive as long as possible. Researchers and clinicians at Mayo Clinic are looking at the potential of cell-based therapies to promote the healing response.

“We don’t know why nerve cells die prematurely,” says Anthony Windebank, M.D. “The hope with this therapy is to protect the neurons that are there and to slow the disease course.”

One cell type derived from the patient’s fat cells, mesenchymal stromal cell (MSC), has been suggested as a possible therapy to treat ALS. MSCs are known to secrete proteins that support the growth and survival of developing and mature neurons. MSCs and cytokines (small proteins) also have a controlling influence on the immune system. Research shows that the immune system has an influence on the progression of ALS.

A novel phase I clinical trial at Mayo Clinic set out to study the safety of MSC therapy. Twenty-seven participants with ALS enrolled in the study and were treated in a MSC dose-escalation safety trial over several months. The study was led by Mayo Clinic neurologists Anthony Windebank, M.D. and Nathan P. Staff, M.D., Ph.D.

The results show the safety protocol is positive and the treatment is safe at the tested dosage levels. The most common side effects were temporary low back and radicular leg pain at the highest dosage levels. There was no sign of tumor formation, which is a concern with cell-based therapies. The study, Safety of intrathecal autologous adipose-derived mesenchymal stromal cells in patients with ALS, is published online in Neurology®, the journal of the American Academy of Neurology.

The Revised ALS Functional Rating Scale questionnaire was taken throughout the study along with clinical examinations. Some participants reported mild, temporary, and subjective clinical improvement lasting two months or less. These effects cannot be interpreted as a positive response to MSC treatment because the trial was not blinded or placebo controlled. Progression of the disease continued in the treated patients.

The results of the safety profile indicate that the research should go forward with a longer study to determine effectiveness, and whether earlier intervention or additional MSC treatments over a longer period of time will produce meaningful results.

“We saw enough of a signal in a subset of patients to indicate that we should go on with a longer study,” says Windebank.

Phase II

The Phase II study will treat a larger group of patients for a longer period of time with the higher dosage levels. The study will include about 60 patients. All participants will receive the treatment. The study will match patients participating in the Pooled Resource Open Access ALS Clinical Trials, PRO-ACT database. The database contains more than 8,500 ALS patients participating in clinical trials. Mayo Clinic statisticians will use the de-identified and merged data from existing public and private ALS clinical trials in the database. The statisticians will match database participants with Phase II study patients on data points such as age at onset, gender, and other factors.

The Phase II study will start mid-2017 and is planned to run for 12 months. The Phase II study is partially funded by the Judith & Jean Pape Adams Charitable Foundation, the Center for Regenerative Medicine, and a grant from Regenerative Medicine Minnesota. The study will begin incrementally while additional funding is sought through additional research grants.

Tags: Anthony Windebank, Mayo Clinic, mayo clinic medical research, Mayo Clinic research, Nathan Staff, News, regenerative medicine, Research, stem cells

COMMENT

jessicasmith107
@jessicasmith107

Posts: 1
Joined: Sep 27, 2017
Posted by @jessicasmith107, Oct 25, 2017

Hi Viewers,
My husband was diagnosed of ALS (Amyotrophic Lateral Sclerosis) 2 years ago at Patton State Hospital California, the doctor told us there was no known cure for the disease, we were given medications to help the symptoms. After 1 year and 2 months, the symptoms has got worse and we had to look for an alternative treatment since the doctors were not helping. I read an article online last 3 month about Dr. Yare herbal healing home in Africa who prepare and sell herbal medicines to cure all kind of disease including ALS/MND, I contacted the herbal Doctor through his email and purchased the ALS herbal remedy, we received the herbal remedy within 3 days and my husband immediately commenced usage, He drank the ALS herbal Tonic Doc. Yare prepared for him. OMG!! after 1 week of usage some of the symptoms like clumsiness and his very slurred speech had stopped, he continue usage the 4th week he’d got a lot better that even the doctors could not believe it. It totally cured him and we have told so many people about it. Now my husband can work a distance freely without any assistant. With doc. Yare, you can get that incurable disease cured. its all thanks to God and also to you Doc. Yare, for your continued help, and wonderful knowledge of God’s life-saving herbs.You are truly a Godsent!! If you have or know anyone still suffering from ALS/MND/MSA/FSHD/MS, Bipolar HIV/AIDS, HSV or any other disease, do contact him on: dryareherbalcurehome@gmail.com Call and Whatsup: +2348148010628, +2348164653711. Website: http://bit.ly/2dBFYeW . Please once you have cured join me to share it with family, friends and anyone you know battling from any disease. Sharing is Caring. Together we Fight to Stay Healthy.

chloedd
@chloedd

Posts: 1
Joined: Oct 31, 2017
Posted by @chloedd, Oct 31, 2017

Chloe Ryan
My dad was diagnosed with ALS. He does not have ALS anymore.ALS herbal remedies i purchased online from Dr Lauren (Good Health Herbs Home) cured my day ALS .pleases anyone out there with ALS,natural herbal remedy is the real things to use, No more toxic medication that clearly state ‘lead to death’. Let real and natural herbal remedy be your medicine. Stay away from vaccines and frankenfood.contact Dr Lauren for your ALS cure (drlauren @ goodhealthherbshome .com), website
www .goodhealthherbshome .com

janicetollis
@janicetollis

Posts: 2
Joined: Jun 02, 2017
Posted by @janicetollis, Nov 14, 2017

I have ADHD, OCD, depression, primary biliary cirrhosis (autoimmune disease) and ALS. I didn’t have health care I just thought it was a stroke, but it started with my voice. When it started to get worse I went to a neurologist. and was diagonised with amyotrophic lateral sclerosis. i was able to walk with assistance nothing was really working to help my condition.I went off the riluzole (with the doctor’s knowledge) and started on amyotrophic lateral sclerosis herbal formula i ordered from Health Herbal Clinic, Just 7 weeks into the Herbal formula treatment I had great improvements with my slurred speech, this is a breakthrough for all amyotrophic lateral sclerosis sufferers, visit Health Herbal Clinic official website www. healthherbalclinic. net or email info@ healthherbalclinic. net.

mary121
@mary121

Posts: 1
Joined: Dec 20, 2017
Posted by @mary121, Dec 20, 2017

Having ALS was the end of he world for me and carrying it for another 2years was hell despite all the medication I was

taking. But doc ABDUL helped me with his herbal cure and for 9months now I am free nd negative. He too can do yours as

well dear. Contact him today on e-mail abdulahiherbalhome @ gmail.com call/whatsapp +2348154691560.
Thank God am free today. Life is worth more than gold.
Doctor ABDUL was life saving.

annenichols
@annenichols

Posts: 1
Joined: Jan 09, 2018
Posted by @annenichols, Tue, Jan 9 8:35am

I was diagnosed with ALS (amyotrophic lateral sclerosis) 15 months ago. At that time riluzole was prescribed. I found I could not tolerate it. did very little to help me. The medical team did even less. My decline was rapid and devastating. The psychological support from the medical centre was non-existent and if it were not for the sensitive care and attention of my primary physician, I would have died. There has been little if any progress in finding a cure or reliable treatment. My ALS got significantly worse and unbearable because of my difficulty catching breath. Last year, i started on a natural ALS Herbal therapy from Mbeki Herbal Clinic, i read a lot of positive reviews from patients who used the treatment and i immediately started on it. I had great relief with this herbal treatment. I am doing very much better now, no case of shortness of breath or difficulty swallowing,, my ALS condition is totally reversed. Visit Mbeki Herbal Clinic website ww w. mbekiherbalclinic. com. This treatment is a miracle!!

skabadani
@skabadani

Posts: 1
Joined: Jan 12, 2018
Posted by @skabadani, Fri, Jan 12 8:52am

Hello and thank you for sharing. My father was recently diagnosed with ALS and we are desperately searching for Alternative ways to slow down the progression of this horrible disease. Among all the other things, the breathing part of this disease is what is concerning more than anything else at the moment so I am very curious if you can provide any more detail information and examples about what you were experiencing prior to taking the herbal supplements. Also can you please comment on legitimacy of the doctor and supplier. I do not mean to be disrespectful to anyone but as you probably know, there are lots of claims out there about alternative and nontraditional treatments and I am just generally suspicious of online claims of cure or reversal, etc…. again, no disrespect but can you please help us with more information in order to feel more positive and optimistic about the information you are providing. Thank you so much and God Bless you and we hope for your continuous and full recovery.

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